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TIA-1, IHC without Interpretation
Test Code90236
CPT Codes
88342
Preferred Specimen
Formalin fixed paraffin embedded tissue in an IHC specimen transport kit
Other Acceptable Specimens
Unstained charged(+) slides submitted in IHC specimen transport kit (x5)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
A.M.
Clinical Significance
TIA-1, a cytoplasmic/granule marker that is associated with cytotoxic lymphocytes, is positive in T-cell and NK large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T or NK phenotype. Most anaplastic large cell lymphomas will also show variable reactivity.
