TCL1, IHC without Interpretation

Test Code

90402

CPT Codes
88342

Preferred Specimen

Formalin-fixed, paraffin-embedded block collected in an IHC Specimen Transport Kit

Minimum Volume

3 slides

Other Acceptable Specimens

5 unstained, positively charged slides collected in an IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received frozen

Methodology
Immunohistochemistry

Setup Schedule

A.M.

Clinical Significance

The T-cell leukemia/lymphoma protein 1 (TCL1) is an AKT kinase regulator that is expressed in B cells up to the germinal stage and in plasmacytoid dendritic cells. TCL1 is strongly expressed, due to the chromosomal rearrangements, t(14;14)(q11;q32) and inv(14)(q11;q32), in 70% of cases of T-cell prolymphocytic leukemia (T-PLL) but is negative in all other mature T-cell lymphomas and leukemias. TCL1 is also expressed in nearly all cases of blastic plasmacytoid dendritic cell neoplasms, and can be used to distinguish this tumor from monocytic neoplasms. High TCL1 levels correlate with the pre-germinal center genetic subtype and are a strong adverse prognostic factor in B-cell chronic lymphocytic leukemia.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.