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Serotonin, Blood (818X)
Test Code29397P
CPT Codes
84260
Preferred Specimen
4 mL whole blood submitted in a Serotonin Kit (provided by Quest Diagnostics) (see instructions)
Patient Preparation
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant. Patient should also avoid tobacco, tea and coffee three days prior to specimen collection.
Minimum Volume
1 mL
Instructions
Proper specimen collection, storage and shipment are critical for serotonin whole blood analysis. Strict adherence to the following specimen collection instructions will ensure the most meaningful results.
1. Draw blood into the EDTA 7.2-mg Vacutainer® tube.
2. After drawing the blood, mix well and immediately transfer all blood to the enclosed container, which contains 35 mg of ascorbic acid.
3. Mix well and freeze immediately.
4. Ship frozen. Expiration date for ascorbic acid container is the same as the EDTA tube provided in the kit.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Received refrigerated • EDTA (lavender-top) collection without ascorbic acid
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 3-5 days
Clinical Significance
Serotonin is produced in excess by carcinoid tumors of the enterochromaffin cell usually in the small intestine, appendix or rectum.