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Sensory Neuropathy Complete Antibody Panel
Test Code15977
CPT Codes
84181, 86255, 82595, 86334, 82784 (x3), 86431, 86235 (x2), 86038, 86021 (x2), 86036, 86364, 83520 (x3)
Includes
ANA Screen, IFA with Reflex to Titer and Pattern, IFA
If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).
ANCA Screen with Reflex to ANCA Titer
If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer, and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed).
Cryoglobulin Screen with Reflex to Cryoglobulin Reflex
If Cryoglobulin Screen is positive, then Cryoglobulin Reflex will be performed at an additional charge (CPT code(s): 86334, 86329).
Ganglioside GD1b Antibodies (IgG, IgM), EIA
Ganglioside GQ1b Antibody (IgG), EIA
Hu Antibody Screen with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is positive, then Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is positive, then Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Immunofixation (IFE), Serum
Immunoglobulins (IgG, IgA and IgM)
If IgA (Immunoglobulin A) is abnormal, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).
Myelin Associated Glycoprotein (MAG) Antibody, with Reflex to MAG-SGPG and MAG, EIA
If MAG Antibody (IgM), WB is positive, then MAG-SGPG Antibody (IgM), EIA and MAG Antibody (IgM), EIA, will be performed at an additional charge (CPT code(s): 83520 x2).
Myeloperoxidase Antibody (MPO)
Proteinase-3 Antibody
Rheumatoid Factor
Sjögren's Antibodies (SS-A, SS-B)
Tissue Transglutaminase (tTG) Antibody (IgA)
If Tissue Transglutaminase (tTG) Antibody (IgA) is detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) with Reflex to Titer will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).
ANCA Screen with Reflex to ANCA Titer
If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer, and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed).
Cryoglobulin Screen with Reflex to Cryoglobulin Reflex
If Cryoglobulin Screen is positive, then Cryoglobulin Reflex will be performed at an additional charge (CPT code(s): 86334, 86329).
Ganglioside GD1b Antibodies (IgG, IgM), EIA
Ganglioside GQ1b Antibody (IgG), EIA
Hu Antibody Screen with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is positive, then Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is positive, then Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Immunofixation (IFE), Serum
Immunoglobulins (IgG, IgA and IgM)
If IgA (Immunoglobulin A) is abnormal, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).
Myelin Associated Glycoprotein (MAG) Antibody, with Reflex to MAG-SGPG and MAG, EIA
If MAG Antibody (IgM), WB is positive, then MAG-SGPG Antibody (IgM), EIA and MAG Antibody (IgM), EIA, will be performed at an additional charge (CPT code(s): 83520 x2).
Myeloperoxidase Antibody (MPO)
Proteinase-3 Antibody
Rheumatoid Factor
Sjögren's Antibodies (SS-A, SS-B)
Tissue Transglutaminase (tTG) Antibody (IgA)
If Tissue Transglutaminase (tTG) Antibody (IgA) is detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) with Reflex to Titer will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
Preferred Specimen
18.9 mL serum collected in a red-top tube (no gel)
Patient Preparation
Overnight fasting is required
Minimum Volume
9.5 mL
Instructions
See individual tests.
Multiple tubes required for testing.
Cryoglobulin Screen and reflex: 3 mL serum required: 2 mL minimum.
Since multiple tubes are needed for this panel, designate one tube exclusively for cryoglobulin and treat it differently from the other tubes collected. Allow blood in the tube designated for cryoglobulin to clot for one (1) hour in a 37° C water bath, incubator, heat block, or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the cryoglobulin serum into one screw-cap vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature.
NOTE: If the sample is NOT kept at 37° C during clotting, the cryoglobulin, if present, can precipitate during centrifugation and be lost in the clot resulting in a false negative result.
Multiple tubes required for testing.
Cryoglobulin Screen and reflex: 3 mL serum required: 2 mL minimum.
Since multiple tubes are needed for this panel, designate one tube exclusively for cryoglobulin and treat it differently from the other tubes collected. Allow blood in the tube designated for cryoglobulin to clot for one (1) hour in a 37° C water bath, incubator, heat block, or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the cryoglobulin serum into one screw-cap vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature.
NOTE: If the sample is NOT kept at 37° C during clotting, the cryoglobulin, if present, can precipitate during centrifugation and be lost in the clot resulting in a false negative result.
Transport Temperature
See individual tests
Specimen Stability
See individual tests
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
See individual assays
Methodology
Immunoassay (IA) • Immunotyping • Immunofixation
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
