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Protein, Total, CSF
Test Code755
CPT Codes
84157
Preferred Specimen
1 mL CSF collected in a plastic screw-cap container
Minimum Volume
0.5 mL
Instructions
Avoid hemolysis
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Spectrophotometry (SP)
Setup Schedule
Set up: Daily; Report available: Next day
Clinical Significance
The CSF normally contains less than 1% of the amount of protein present in plasma. Clinical disorders associated with increased CSF protein include traumatic spinal tap, increased blood-CSF permeability due to meningitis or hemorrhage, endocrine/metabolic disorders, drug toxicity, and CSF circulation disorders. Clinical disorders associated with decreased CSF total protein include CSF leakage from dural tear, increased intracranial pressure, removal of CSF, hyperthyroidism and leukemia. Young children (6 months to 2 years) also have decreased CSF total protein.