Pheochromocytoma Evaluation (10520X)

Test Code

10520N

CPT Codes
82382, 83835, 82570

Includes

Total Catecholamines, Total Metanephrines, Creatinine, Catecholamine/Creatinine Ratio (calculated), Metanephrine/Creatinine Ratio (calculated)

Preferred Specimen

14 mL 24-hour urine with 25 mL 6N HCl collected in a 24-hour urine container

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (aldomet), alpha blockers (dibenzyline) should be avoided 18-24 hours prior to specimen collection.

Minimum Volume

5.5 mL

Other Acceptable Specimens

Unpreserved urine

Instructions

After urine collection, add 25 mL of 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record 24-hour urine volume on test requisition and urine vial. Record patients age on test requisition and urine vial.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 8 hours
Refrigerated: 8 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature

Methodology
High Performance Liquid Chromatography (HPLC) • LCMSMS • Kinentic Alkaline Picrate

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

A.M. Sets up 5 days a week.

Clinical Significance

Pheochromocytoma is a tumor of the adrenal gland associated with headaches, cyclic changes in blood pressure, sweating, and other symptoms. Pheochromocytomas produce catecholamines and metanephrine.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.