A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Perforin, IHC without Interpretation
Test Code90358
CPT Codes
88342
Preferred Specimen
Formalin fixed paraffin embedded tissue in an IHC specimen transport kit
Other Acceptable Specimens
Unstained charged (+) slides collected in IHC specimen transport kit (x5)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
A.M.
Clinical Significance
Perforin, a protein found within cytoplasmic granules, is a marker of cytotoxic lymphocytes. It is frequently positive, along with granzyme B, in extranodal natural killer (NK) cell lymphomas, aggressive NK cell leukemias and large granular lymphocyte (LGL) leukemias. Unlike TIA1, it is negative in hepatosplenic T-cell lymphoma.