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PAX-5, IHC without Interpretation
Test Code40021X
CPT Codes
88341
Preferred Specimen
Formalin fixed paraffin embedded tissue in an IHC specimen transport kit
Other Acceptable Specimens
4-micron unstained slides (x5) • Fixed tissue
Instructions
Tumor paraffin block (formalin-fixed only) or five 4-micron unstained sections on Poly-L-Lysine or Silane coated slides.
See Specimen Collection Section, Oncology.
Ship at room temperature.
Do not place paper labels with adhesive backing on slides. Use pencil or xylene resistant pen to write on the frosted end of the slide only. Pathology report is required.
See Specimen Collection Section, Oncology.
Ship at room temperature.
Do not place paper labels with adhesive backing on slides. Use pencil or xylene resistant pen to write on the frosted end of the slide only. Pathology report is required.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Tissue in formalin
Methodology
Immunohistochemistry (IHC)
Setup Schedule
A.M.
Clinical Significance
Pax genes are a family of developmental control genes that encode nuclear transcription factors and have been implicated in the control of mammalian development. PAX-5 is a B cell speciric transcription factor that is expressed in pro B-cells, pre-B and mature B cells, and subsequently in all stages of B cell development until that plasma cell stage in which it is down regulated.
