Pan-cytokeratin (AE1/AE3 and PCK26), IHC with Interpretation

Test Code

40018X

CPT Codes
88342

Preferred Specimen

Formalin fixed paraffin embedded tissue in an IHC specimen transport kit

Instructions

Pathology report is required

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Tissue in formalin

Methodology
Immunohistochemical Stain

Setup Schedule

A.M.

Clinical Significance

Anti-cytokeratin cocktail (AE1/AE3 & PCK26) is well suited to distinguish epithelial carcinoma from non-epithelial malignancies and is used to aid epithelial tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in recognizing epithelial cells and carcinomas.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.