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p53 Oncoprotein, IHC with Interpretation (36162X)
Test Code41061N
CPT Codes
88342
Preferred Specimen
Formalin fixed paraffin embedded tissue in an IHC specimen transport kit
Other Acceptable Specimens
4 micron unstained slides (x5) • Fixed tissue • Tissue in neutral buffered formalin
Instructions
Tumor paraffin block or five 4-micron unstained sections on Poly-L-Lysine or Silane coated slides. See Specimen Collection Section, Oncology. Please submit stained H & E slide and a copy of the pathology report. Ship at room temperature. Pathology report is required.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Methodology
Immunohistochemical Assay (IHC)
Setup Schedule
A.M. Sets up 6 days a week.
Report Available
Reports in 2 to 3 days.
Clinical Significance
p53 is a tumor suppressor gene. Mutations of the p53 gene are detectable in approximately half of all carcinomas. Detection of p53 by Immunohistochemistry serves as a surrogate marker of the mutant p53 gene. Generally, the presence of mutant p53 gene expression is associated with a poorer prognosis.
