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MUM1, IHC with Interpretation
Test Code16957
CPT Codes
88342
Preferred Specimen
Formalin-fixed paraffin embedded tissue in IHC specimen transport kit
Other Acceptable Specimens
Unstained charged (+) slides (x5) in IHC specimen transport kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Sample other than paraffin block
Methodology
Immunohistochemical Stain
Setup Schedule
A.M.
Report Available
Reports in 2 to 3 days.
Clinical Significance
Multiple myeloma oncogene-1 (MUM1) is a 50 kDa protein encoded by the MUM1 gene. IRF4/MUM1 is expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B cells located in the "light zone". This antibody labels MUM1 protein in centrocytes and their progeny, plasma cells, activated T cells, and a wide spectrum of hematolymphoid neoplasms derived from these cells.