A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
MSH6, IHC without Interpretation
Test Code16252
CPT Codes
88342
Preferred Specimen
Formalin fixed paraffin embedded tissue in an IHC specimen transport kit
Other Acceptable Specimens
Unstained charged(+) slides (x5)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimen other than paraffin block or slide
Methodology
Immunohistochemical Stain
Setup Schedule
A.M.
Clinical Significance
MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as hereditary non-polyposis colon cancer (HNPCC). This assay is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.