A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

MSH6, IHC with Interpretation

Test Code
16938


CPT Codes
88342

Preferred Specimen
Formalin-fixed paraffin embedded tissue in IHC specimen transport kit


Other Acceptable Specimens
Unstained charged(+) slides (x5)


Transport Container
IHC specimen transport kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimen other than paraffin block or slide


Methodology
Immunohistochemical Stain

Setup Schedule
A.M.


Report Available
Reports in 2 to 3 days.


Clinical Significance
MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as hereditary non-polyposis colon cancer (HNPCC). This assay is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.