A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Lambert-Eaton Syndrome Antibody Panel
Test Code11306X
CPT Codes
86041, 86043, 86596, 86255
Includes
Acetylcholine Receptor Binding Antibody
Acetylcholine Receptor Modulating Antibody
Striated Muscle Antibody with Reflex to Titer
Voltage Gated Calcium Channel Antibody Assay
If Striated Muscle Antibody Screen is positive, then Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Acetylcholine Receptor Modulating Antibody
Striated Muscle Antibody with Reflex to Titer
Voltage Gated Calcium Channel Antibody Assay
If Striated Muscle Antibody Screen is positive, then Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Preferred Specimen
2 mL serum
Minimum Volume
0.9 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
See individual assays
Methodology
Immunoassay (IA) • Immunofluorescence Assay (IFA) • Radiobinding Assay (RBA)
FDA Status
*This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
Clinical Significance
Lambert-Eaton myasthenic syndrome is a paraneoplastic phenomena associated with small cell lung cancer. There is a decrease of voltage-gated calcium channels on presynaptic nerve terminals due to an auto-antibody reactive with the channels. There is an associated proximal muscle weakness and often coexisting thyroid autoimmune disease and vitiligo.