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JC Polyoma Virus DNA, Qualitative Real-Time PCR, Serum or Plasma
Test Code17220X
CPT Codes
87798
Preferred Specimen
0.7 mL plasma collected in an EDTA (lavender-top) tube
Minimum Volume
0.3 mL
Other Acceptable Specimens
Plasma collected in: ACD A (yellow-top) tube or PPT (white-top) tube • Serum
Transport Temperature
Frozen
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Methodology
Real-Time Polymerase Chain Reaction
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 7 days a week
Clinical Significance
JC polyoma virus is the cause of progressive multifocal leukoencephalopathy (PML), a demyelinating neurologic disease of immunosuppressed patients. This test detects JC polyoma virus DNA in CSF, urine or plasma. Detection of virus in specimens from AIDS and other severely immune compromised patients may indicate disease. Serum antibodies are not helpful in diagnosing PML as antibodies are common in the general population. JVC can also be detected in the urine of 3% of pregnant women, but is not associated with proven disease.
