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Human Platelet Antigen 1 Genotype
Test Code10707X
CPT Codes
81105
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Refrigerated: 14 days
Frozen: Unacceptable
Methodology
DNA-Based Capture Binding Assay
Setup Schedule
A.M. Sets up 1 day a week.
Clinical Significance
Human Platelet Antigen (HPA) polymorphism can lead to alloimmunization that clinically can manifest as neonatal alloimmune thrombocytopenia or post-transfusion thrombocytopenia purpura. HPA-1 genotyping allows screening for potential neonatal immunization in pregnancy.