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Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot, CSF
Test Code90122
CPT Codes
86255 (x3)
Includes
Hu Antibody Screen with Reflex to Titer and Western Blot, CSF
Yo Antibody Screen with Reflex to Titer and Western Blot, CSF
Ri Antibody Screen with Reflex to Titer and Western Blot, CSF
If Hu Antibody Screen, IFA, CSF is Positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is Positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA, CSF is Positive, then Yo Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB, CSF is Positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA, CSF is Positive, then Ri Antibody, WB, CSF will be performed at an additional charge (CPT codes: 84181).
If Ri Antibody, WB, CSF is Positive, then Ri Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
Yo Antibody Screen with Reflex to Titer and Western Blot, CSF
Ri Antibody Screen with Reflex to Titer and Western Blot, CSF
If Hu Antibody Screen, IFA, CSF is Positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is Positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA, CSF is Positive, then Yo Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB, CSF is Positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA, CSF is Positive, then Ri Antibody, WB, CSF will be performed at an additional charge (CPT codes: 84181).
If Ri Antibody, WB, CSF is Positive, then Ri Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
Preferred Specimen
2.4 mL CSF in a sterile screw-cap container
Patient Preparation
Overnight fasting is preferred
Minimum Volume
1.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
Clinical Significance
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
