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Heterophile, Mono Screen
Test Code654
CPT Codes
86308
Preferred Specimen
1 mL serum
Minimum Volume
0.2 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Agglutination
Setup Schedule
A.M.; Evening Sets up 6 days a week.
Limitations
Failure to develop heterophil antibodies occurs frequently in children and in about 10% of adults with infectious mononucleosis. In these cases, development of EBV antibodies is applicable. 955 specificity. Less than 2% false-positives have occurred in patients with Hodgkin disease, acute lymphoma, acute lymphomatic leukemia, infectious hepatitis, pancreatic carcinoma, cytomegalovirus, Burkitt lymphoma, rheumatoid arthritis, malaria and rubella.
Clinical Significance
Heterophile antibodies, in patients with infectious mononucleosis, may be present as early as the fourth day of illness, and by the twenty-first day of illness, 90% of patients will exhibit a positive test. The Epstein-Barr virus causes infectious mononucleosis.
