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Herpes Simplex Virus 1 and 2, IHC without Interpretation
Test Code16721X
CPT Codes
88341
Preferred Specimen
Formalin-fixed paraffin-embedded tissue block
Other Acceptable Specimens
4-micron unstained slides (x5) • Fixed tissue • Tissue in neutral buffered formalin
Instructions
Do not freeze
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M.
Clinical Significance
Two serotypes of the herpes simplex virus, HSV-1 (also known as type one or oral) and HSV-2 (type 2 or genital), can establish lifelong latent infections with sensory ganglia. Periodically, the virus reactivates and can cause recurrent cold sores, encephalitis and eye and genital infections. HSV-1 usually establishes latency in the trigeminal ganglion, a collection of nerve cells near the ear. From there, it tends to recur on the lower lip or face. HSV-2 usually resides in the sacral ganglion at the base of the spine. From there, it reiterates in the genital area. When no symptoms are present, HSV lies dormant in the bodies of the nerve cells. During and outbreak, though, it replicates within axons near the skin.