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Fondaparinux Sodium (Xa Inhibition)
Test Code16103
CPT Codes
80299
Preferred Specimen
1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
0.5 mL
Instructions
Collect 1 mL citrated plasma from a light blue-top tube (3.2% citrate), place in a sterile, plastic screw-capped vial, freeze and ship frozen.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days
Refrigerated: Unacceptable
Frozen: 21 days
Methodology
Anti-Xa Chromogenic
Setup Schedule
A.M. Sets up 5 days a week.
Clinical Significance
Fondaparinux sodium (Arixtra) is a factor Xa inhibitor indicated for the prophylaxis and treatment of deep venous thrombosis and pulmonary embolism in certain patient populations. The antithrombotic activity of Arixtra is the result of antithrombin III-mediated selective inhibition of Factor Xa. Neutralization of factor Xa interrupts thrombin formation and thrombus development. The anti-Factor Xa activity of the drug can be measured using the chromogenic anti-Xa method using Arixtra as the calibrator.