FISH, Ewing/PNET, EWSR1, 22q12 Rearrangements

Test Code
16112


CPT Codes
88271 (x2), 88275

Preferred Specimen
Fresh-fixed, paraffin-embedded specimen or
3 mL bone marrow collected in a sodium heparin (green-top) tube or
5 x 5 mm tissue biopsy collected in transport medium


Minimum Volume
1 mL


Instructions



Transport Temperature
Room temperature


Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. **Do not reject**


Methodology
Fluorescence in situ Hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Sets up 7 days a week.


Clinical Significance
A FISH Ewing sarcoma assay by using the LSI (R) EWSR1 (22q12) Dual Color, Break Apart Rearrangement Probe (Vysis) to identify chromosomal rearrangements of the EWSR1 gene region.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.