Epstein-Barr Virus, ISH without Interpretation

Test Code

16689X

CPT Codes
88365

Preferred Specimen

Formalin-fixed paraffin-embedded tissue block

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Do Not Freeze

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Sample in fixative

Methodology
In-Situ Hybridization

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Sets up Mon through Sat AM

Clinical Significance

The presence of Epstein-Barr virus (EBV) in tumors or reactive tissues can be detected by expression of the EBV-associated small RNAs (EBERs) using in situ hybridization. EBER expression is seen in all EBV-associated malignancies including classical Hodgkin lymphoma (most commonly mixed cellularity type), nasopharyngeal carcinoma, post-transplant B-cell lymphoproliferative disorders, a subset of diffuse large B-cell lymphomas, extranodal NK/T-cell lymphoma, nasal type, and some childhood T-cell lymphoproliferative disorders.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.