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Cryoglobulin (% Cryocrit), Serum
Test Code36562
CPT Codes
82595
Preferred Specimen
6 mL serum collected in each of three separate red-top tubes (no gel)
Patient Preparation
Overnight fasting is required
Minimum Volume
3 mL
Instructions
Allow serum sample to clot for one (1) hour in a 37°C water bath, oven, incubator, or heat block. After clotting, centrifuge the specimen for 10 minutes at 1600 RCF(G) utilizing one of the 3 options below:
1) In a "warm" centrifuge at 37°C.
2) In a bench-top centrifuge placed in a "warm room" at 37°C.
3) At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 1600 RCF(G).
After centrifuging, decant serum into a screw-cap vial. Transport at room temperature.
NOTE: If the sample is NOT kept at 37°C during all processing steps, the cryoprecipitate if present can precipitate out of solution and be lost in the clot or during the centrifugation process and result in a false negative result. DO NOT REFRIGERATE OR FREEZE. Note: No tests can be added or poured off this tube; cryocrit and cryoglobulin evaluation only.
1) In a "warm" centrifuge at 37°C.
2) In a bench-top centrifuge placed in a "warm room" at 37°C.
3) At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 1600 RCF(G).
After centrifuging, decant serum into a screw-cap vial. Transport at room temperature.
NOTE: If the sample is NOT kept at 37°C during all processing steps, the cryoprecipitate if present can precipitate out of solution and be lost in the clot or during the centrifugation process and result in a false negative result. DO NOT REFRIGERATE OR FREEZE. Note: No tests can be added or poured off this tube; cryocrit and cryoglobulin evaluation only.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable
Refrigerated: Unacceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Received refrigerated • Received frozen • Serum Separator Tube (SST®) • Icteric sample
Methodology
Visual Inspection
Setup Schedule
Set up: Daily; Report Available: 5-7 days
Clinical Significance
The cryocrit is primarily intended for following a patient with previously defined and quantitated cryoglobulins. The cryocrit may consist of cryoglobulins, fibrins or mixtures of cryoglobulins and fibrins. If not previously characterized, consider ordering Cryoglobulin Screen with Reflex to Cryoglobulin Profile, Serum.
