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Cryoglobulin (% Cryocrit), Serum
Test Code36562
CPT Codes
82595
Preferred Specimen
3 mL serum collected in a red-top tube (no gel)
Patient Preparation
Overnight fasting is required
Minimum Volume
2 mL
Instructions
Allow blood to clot for one (1) hour in a 37° C water bath, incubator, heat block or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the serum into one screw-cap vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature.
Note: If the sample is NOT kept at 37° C during clotting, the cryoglobulin, if present, can precipitate during centrifugation and be lost in the clot resulting in a false negative result.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Serum separator tube (SST) • Icteric sample
Methodology
Visual Inspection
Setup Schedule
Set up: Daily; Report Available: 5-7 days
Clinical Significance
The cryocrit is primarily intended for following a patient with previously defined and quantitated cryoglobulins. The cryocrit may consist of cryoglobulins, fibrins or mixtures of cryoglobulins and fibrins. If not previously characterized, consider ordering Cryoglobulin Screen with Reflex to Cryoglobulin Profile, Serum.
