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C-Peptide Response to Glucose, 5 Specimens
Test Code31345
CPT Codes
84681 (x5)
Preferred Specimen
1 mL serum per specimen
Patient Preparation
Patients should fast 12 hours prior to collection
Minimum Volume
0.5 mL per specimen
Instructions
Draw fasting specimen. Administer oral glucose solution (1.75 g/kg body weight or 75 g maximum). Collect 1 mL serum for each timed specimen post glucose dose. All tubes must be clearly marked with time drawn. Submit all tubes with one test requisition.
Reference ranges available: Fasting, 30, 60, 90, 120, 150, 180, 240 and 300 minutes post glucose.
Reference ranges available: Fasting, 30, 60, 90, 120, 150, 180, 240 and 300 minutes post glucose.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen -20° C: 7 days
Frozen -70° C: Not available
Refrigerated: 7 days
Frozen -20° C: 7 days
Frozen -70° C: Not available
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Plasma
Methodology
Immunoassay (IA)
Setup Schedule
P.M.
Clinical Significance
C-Peptide is useful in the evaluation of pancreatic beta cell function (e.g., helping distinguish type 1 from type 2 diabetes mellitus, or monitoring patients who have received islet cell or pancreatic transplants) and for determining the source of insulin in patients with hyperinsulinemic hypoglycemia. (e.g., distinguishing insulin-secreting tumors from exogenous insulin administration). It is also sometimes measured as an additional means (more resistant to hemolysis than is insulin itself) for evaluating glucose tolerance tests.