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COX-2, IHC with Interpretation

Test Code
90157


CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin-embedded block collected in an IHC Specimen Transport Kit


Minimum Volume
3 slides


Other Acceptable Specimens
5 unstained, positively charged slides collected in an IHC Specimen Transport Kit


Instructions
Please include surgical pathology report


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable


Methodology
Immunohistochemistry

Setup Schedule
Set up: Mon-Sat; Report available: 2-4 days


Clinical Significance
Tissue cycloxgenase (COX) 2 is an enzyme expressed in the cytoplasm of many cells types. COX2 overexpression has been associated with adverse prognosis in carcinomas of the colon, breast, pancreas, and adenocarcinoma of the lung. Its activity, but not its expression level, is inhibited by nonsteroidal anti-inflammatory agents.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.