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Corticosterone
Test Code6547
CPT Codes
82528
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, EDTA (royal blue-top) tube, sodium heparin (green-top) tube
Instructions
Separate serum after clotting. An early morning specimen is preferred.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 1 year
Refrigerated: 14 days
Frozen: 1 year
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night Sets up 1 day a week.
Clinical Significance
Measurement of corticosterone may help confirm the diagnosis of the very rare aldosterone deficiency disorder, corticosterone methyl oxidase (18-hydroxylase) enzyme deficiency where the ratio of corticosterone to 18-hydroxycosticosterone may be increased.