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Complement Component C3c and C4c
Test Code5704
CPT Codes
86160 (x2)
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 4 days
Frozen: 21 days
Refrigerated: 4 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Immunoturbidimetric
Setup Schedule
Set up: Sun-Fri; Report available: 2-4 days
Clinical Significance
Decreased concentrations of both C3 and C4 suggest activation of the classical pathway, whereas decreased concentration of just C3 suggests activation of the alternative pathway. Both complement factors may be used to monitor activity of patients with systemic lupus erythematosus (SLE) and immune complex-induced vasculitis.
