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Collagen Type I C-Telopeptide (CTx)
Test Code17406
CPT Codes
82523
Preferred Specimen
1 mL serum
Patient Preparation
Minimum of 12 hours fasting is required. Fasting morning collection 8-10 am. (Diurnal variations cause elevated levels at night.)
Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Minimum Volume
0.5 mL
Instructions
Allow blood to clot (30-60 minutes) at room temperature. Centrifuge and separate the serum from the cells and transfer serum to a clean transport tube. Freeze as soon as possible.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 16 hours
Refrigerated: 72 hours
Frozen: 90 days
Refrigerated: 72 hours
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate to gross hemolysis • Grossly lipemic • Gross icteric
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat; Report available: 1-3 days
Clinical Significance
CTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss.
