Chronic Lymphocytic Leukemia (CLL) Prognostic Panel, Comprehensive

Test Code

17239

CPT Codes
82232, 81263, 88184, 88185 (x2), 88237, 88264, 88271 (x6), 88275 (x3)

Includes

Beta-2-Microglobulin, Serum
Chromosome Analysis, CLL/LPD
Chronic Lymphocytic Leukemia, IgVH Mutation Status, Cell-based
CD38+ CLL cells
FISH, B-Cell Chronic Lymphocytic Leukemia Panel
ZAP-70

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube and
16 mL whole blood collected in a sodium heparin (green-top) tube and
1 mL serum

Minimum Volume

3 mL EDTA whole blood • 10 mL sodium heparin whole blood • 0.5 mL serum

Instructions

See individual tests

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Lipemia

Methodology
Culture • Flow Cytometry (FC) • Fluorescence in situ Hybridization (FISH) • Immunoturbidometric • Karyotype • Polymerase Chain Reaction (PCR) • Sequencing

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

See indidivual assays

Clinical Significance

Chronic Lymphocytic leukemia is the most common leukemia in the Western world. The disease is chronic and most patients may not require therapy in the early stage of the disease. However, in some patients the disease can be aggressive and within a year the tumor mass may increase significantly imposing serious health problems to the patient. It is difficult to determine based on clinical presentation which patient will progress faster than the others. Therefore, there is a need to use more accurate prognostic indicator to predict the clinical course of this disease. The recent advances in CLL therapy and biology made it possible to develop new tests and a combination of these tests.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.