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Chromosome Analysis, Tissue
Test Code14593
CPT Codes
88233, 88262
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Includes
*** Test may be replaced by %39650 Cytogenetics Communication and %39667 Chromosome Analysis, Tissue, No Growth ***
Preferred Specimen
5 x 5 mm tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics
Minimum Volume
2 x 3 mm
Other Acceptable Specimens
Tissue collected in sterile saline
Instructions
See Genetics Specimen Collection Section for detailed specimen instructions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Formalin-fixed
Methodology
Karyotype • Microscopy • Tissue Culture
Setup Schedule
A.M. Sets up 7 days a week.
Clinical Significance
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.