CD35, IHC with Interpretation

Test Code

19997X

CPT Codes
88342

Preferred Specimen

Formalin fixed paraffin embedded tissue in IHC specimen transport kit

Instructions

Pathology report is required

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Tissue in formalin

Methodology
Immunohistochemical Stain

Setup Schedule

A.M.

Clinical Significance

The CD35 antigen, also known as CR1 or C3b/C4b R, is a transmembrane protein of 160 to 250 kD which binds complement components C3b and C4b. It mediates phogocytosis by neutrophils and monocytes of particles coated with C3b or C4b. CD35 antigen has an inhibitory effect on complement activation by both the classical and alternative pathoways. CD35 antigen is reported to be found on erythrocytes, B cells, a subset of T cells, monocytes, macrophages cultured in vitro, neutrophils, eosinophils, glomerular podocytes and follicular dendritic cells. Decreased levels of CD35 antigen has been reported on B cells in patients with HIV infection.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.