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CD21, IHC with Interpretation
Test Code40037X
CPT Codes
88342
Preferred Specimen
Formalin fixed paraffin embedded tissue in an IHC specimen transport kit
Instructions
Pathology report is required
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Tissue in formalin
Methodology
Immunohistochemical Stain
Setup Schedule
A.M.
Clinical Significance
CD21 antigen is a type I integral membrane glycoprotein of molecular weight 140 kD, which functions as the receptor for the C3d fragment of the third complement component. The CD21 molecule, present on mature B cells,is involved in transmitting growth-promoting signals to the interior of the B cell and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be found in B cell chronic lymphocytic leukemias and in a subset of T cell acute lymphocytic leukemias, but is absent on T lymphocytes, monocytes and granulocytes. CD21 antigen is also reported to be expressed in follicular dendritic cells and in follicular and centrocytic lymphomas, mature leukemias and lymphomas and at high density in follicular dendretic cells.