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Catecholamines, Total, Suppression by Clonidine, Plasma (10068X)
Test Code10068N
CPT Codes
82383 (x4)
Includes
Catecholamines, Total: Baseline, 1-hour, 2-hours, 3-hours
Preferred Specimen
2 mL frozen plasma collected in a sodium heparin (green-top) for each specimen
Patient Preparation
Patients should be resting supine for 1 hour in a non-stressful environment. An indwelling catheter should be placed 30 min before collection of the baseline sample.
Minimum Volume
1 mL (each specimen)
Other Acceptable Specimens
EDTA (lavender-top) tube
Instructions
Collect baseline sample before administration of clonidine (0.3 mg per 70 kg body weight). Collect samples at 1, 2 and 3 hours using indwelling catheter.
Note: Indwelling catheter should be placed 30 min before collection of the baseline sample.
Note: Indwelling catheter should be placed 30 min before collection of the baseline sample.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 6 hours
Refrigerated: 6 hours
Frozen: 31 days
Refrigerated: 6 hours
Frozen: 31 days
Methodology
Liquid Chromatography/Mass Spectrometry
Setup Schedule
Set up: Mon-Fri; Report available: 3-6 days
Clinical Significance
Catecholamines include the hormones epinephrine, norepinephrine, and dopamine. Catecholamines, along with VMA, are produced in chromaffin cell tumors, pheochromocytoma, ganglioneuroma, and neuroblastoma. Symptoms of pheochromocytomas include episodic hypertension, headaches, sweating, heart palpitations, and anxiety.
