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Catecholamines, Fractionated, Upright, Plasma
Test Code16382
CPT Codes
82384
Includes
Epinephrine, Norepinephrine, Dopamine, Catecholamines Total
Preferred Specimen
2 mL frozen plasma collected in a sodium heparin (green-top) tube
Patient Preparation
Fasting overnight is preferred.
If baseline levels of the catecholamines or their metabolites are desired, the patient should abstain from any of the interference list for optimally 3 days (minimum of 8 to 12 hours for tea, coffee, alcohol, tobacco and strenuous exercise - minimum of 18 to 24 hours for others) before the specimen is collected.
Patients should be relaxed in upright position before blood is drawn. States of anxiety and stress can cause fluctuations in the catecholamine levels. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection.
Minimum Volume
1 mL
Other Acceptable Specimens
Frozen plasma collected in: EDTA (lavender-top) tube
Instructions
Draw specimen in a pre-chilled green-top Vacutainer®. Plasma should be separated in a refrigerated centrifuge within 30 minutes of collection and then frozen immediately at -20° C in plastic vials. Each specimen will be invoiced separately.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 6 hours
Refrigerated: 6 hours
Frozen: 30 days
Refrigerated: 6 hours
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Received refrigerated
Methodology
Liquid Chromatography/Mass Spectrometry (LC/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri; Report available: 3-6 days
Clinical Significance
Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (Pheochromocytomas, Neuroblastomas, and Gangliomas) and with the evaluation of Orthostatic Hypotension.