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Antiphospholipid Syndrome Diagnostic Panel
Test Code19872
CPT Codes
86147 (x3), 86146 (x3), 85730, 85613
Includes
Cardiolipin Antibodies (IgA, IgG, IgM)
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
Lupus Anticoagulant Evaluation with Reflex (PTT-LA and dRVVT with Reflex Confirmations)
If PTT-LA Screen is prolonged (>40 seconds), then Hexagonal Phase Confirm is performed at an additional charge (CPT code(s): 85598).
If Hexagonal Phase Confirm is positive or weakly positive, then Thrombin Clotting Time will be performed at an additional charge (CPT code(s): 85670).
If dRVVT Screen is prolonged (>45 seconds), then dRVVT Confirmation will be performed at an additional charge (CPT code(s): 85597).
If dRVVT Confirm is positive, then dRVVT 1:1 Mix will be performed at an additional charge (CPT code(s): 85613).
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
Lupus Anticoagulant Evaluation with Reflex (PTT-LA and dRVVT with Reflex Confirmations)
If PTT-LA Screen is prolonged (>40 seconds), then Hexagonal Phase Confirm is performed at an additional charge (CPT code(s): 85598).
If Hexagonal Phase Confirm is positive or weakly positive, then Thrombin Clotting Time will be performed at an additional charge (CPT code(s): 85670).
If dRVVT Screen is prolonged (>45 seconds), then dRVVT Confirmation will be performed at an additional charge (CPT code(s): 85597).
If dRVVT Confirm is positive, then dRVVT 1:1 Mix will be performed at an additional charge (CPT code(s): 85613).
Preferred Specimen
3 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
2 mL
Instructions
Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Grossly lipemic • Received room temperature • Received refrigerated • Serum
Methodology
Immunoassay (IA) • Photo-Optical Clot Detection
Setup Schedule
See individual assays
Clinical Significance
This assay may be useful in supporting or ruling out a diagnosis of antiphospholipid syndrome.