Aldosterone, Response to ACTH Stimulation, LC/MS

Test Code

17832X

CPT Codes
82088 (x2)

Includes

Aldosterone, Baseline
Aldosterone, 60 minutes

Preferred Specimen

1 mL serum collected in each of two separate red-top tubes (no gel)

Minimum Volume

0.25 mL in each of two separate tubes

Other Acceptable Specimens

Plasma collected in each of two separate EDTA (lavender-top), sodium heparin (green-top) or lithium heparin (green-top) tubes

Instructions

Draw baseline specimen. Draw another specimen 60 minutes after stimulation.
SST tubes are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes. Draw "upright" samples at least 1/2 hour after patient sits up.

Note: Cortrosyn (cosyntropin) not supplied by the laboratory. This test cannot be collected at a Patient Service Center.

Transport Temperature

Frozen

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate to gross hemolysis • Samples collected in Serum Separator Tubes (SST®)

Methodology
Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

A.M.

Clinical Significance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.