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17-Hydroxyprogesterone Neonatal/Infant
Test Code17654
CPT Codes
83498
Preferred Specimen
0.5 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.25 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, EDTA (royal blue-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Instructions
A special sample handling bulletin is required for this assay in order to assure expedited testing. Contact Client Services at 1-800-553-5445 to request this special service.
SST tubes are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.
SST tubes are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 2 years
Refrigerated: 7 days
Frozen: 2 years
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Serum separator tubes (SST) • Glass tubes • Received room temperature
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night Sets up 6 days a week.
Clinical Significance
17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of Cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring Cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.
