Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid (MSP3)

Test Code

12145

CPT Codes
83521<br>Restricted Client Code

Includes

Kappa free light chain will be performed by nephelometry on all samples.
When kappa free light chain results are 0.0600 mg/dL or more, Serum Bands (OLIGS) and CSF Bands (OLIGC) the oligoclonal banding tests will be performed at an additional charge.
If the time of testing exceeds the specimen stability for oligoclonal banding tests (ie, 14 days), only kappa free light chain will be performed.

Preferred Specimen

1 mL serum and 1 mL CSF

Minimum Volume

0.5 mL serum • 0.5 mL CSF

Instructions

Both serum and spinal fluid are required. Spinal fluid must be obtained within 1 week of serum collection.
1. Centrifuge and aliquot serum within 2 hours of collection.
2. Label specimens as spinal fluid and serum.

Transport Container

Serum separator tube (SST) and Sterile vial

Transport Temperature

Frozen

Specimen Stability

Serum
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 14 days

CSF
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis

Methodology
KCSFP: Nephelometry • OLIGC, OLIGS: Isoelectric Focusing (IEF) with IgG Immunoblot Detection

Setup Schedule

Sets up 5 days a week.

Report Available

Reports in 3 to 5 days.

Clinical Significance

Diagnosing multiple sclerosis, especially helpful in patients with equivocal clinical or radiological findings.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.