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Creatinine Clearance
Test Code7943
CPT Codes
82575
Includes
Creatinine (serum and urine)
eGFR
Creatinine Clearance (calculation)
CPT code 81050 may be added at an additional charge for volume measurement
eGFR
Creatinine Clearance (calculation)
CPT code 81050 may be added at an additional charge for volume measurement
Preferred Specimen
10 mL aliquot from a well-mixed, 24-hour urine collection - no preservative
and 1 mL serum
and 1 mL serum
Minimum Volume
0.5 mL urine • 0.5 mL serum
Other Acceptable Specimens
Urinalysis transport tube (yellow-top, blue fill line, preservative tube) • 1 mL plasma collected in sodium heparin (green-top) or lithium heparin (green-top) tube
Instructions
Record total volume and collection duration on specimen container and test requisition. Indicate the patient's height (in feet and inches) and weight (in lbs.) on test requisition.
Note: A serum creatinine level must be collected within 24 hours of the beginning or ending of the urine collection.
Note: A serum creatinine level must be collected within 24 hours of the beginning or ending of the urine collection.
Transport Temperature
Room temperature
Specimen Stability
Serum and urine
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly icteric • Anticoagulants other than heparin
Methodology
Spectrophotometry (SP)
Setup Schedule
Set up: Daily; Report available: Next day
Clinical Significance
Creatinine Clearance is used to evaluate the glomerular filtration rate (GFR). Clearance is defined as that volume of plasma from which a measured amount of substance could be completely eliminated into the urine per unit of time. Daily creatinine production is fairly constant except when there is massive injury to muscle.
