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ADmark® Alzheimer's Evaluation
Test Code93798
CPT Codes
Restricted Client Code
Preferred Specimen
2 mL CSF submitted in a polypropylene tube and
8 mL whole blood collected in two EDTA (lavender-top) tubes
8 mL whole blood collected in two EDTA (lavender-top) tubes
Minimum Volume
0.5 mL CSF • 6 mL whole blood
Instructions
CSF: Tubes other than polypropylene are not acceptable.
Please label each specimen with two forms of patient identification. These forms of identification must also appear on the requisition form.
Note: Whole blood-DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old.
Please label each specimen with two forms of patient identification. These forms of identification must also appear on the requisition form.
Note: Whole blood-DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old.
Transport Container
CSF: Polypropylene transfer tube
Whole blood: EDTA (lavender-top) tube
Whole blood: EDTA (lavender-top) tube
Transport Temperature
CSF: Frozen
Whole blood: Room temperature
Whole blood: Room temperature
Specimen Stability
CSF
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: 4 months
Whole blood
Room temperature: 10 days
Refrigerated: 10 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
CSF specimens that arrive in non-polypropylene tubes • CSF specimens w/cell count >500 erythrocytes/mm3
Methodology
ELISA • Restriction Fragment Length Polymorphism (RFLP)
Setup Schedule
Set up: Mon, Wed; Report available: 14-21 days
Clinical Significance
Detection of ApoE2, E3, E4 alleles and levels of Phosphorylated-Tau protein, Total-Tau protein, and Ab42.
