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HPV Genotypes 16 and 18, Cervical
Test Code93255
CPT Codes
87625<br><strong>***Restricted Use*** This code is available to Client # 23 ONLY</strong>
Preferred Specimen
ThinPrep®: 3 mL of PreservCyt® fluid
SurePath™: 2 mL of SurePath™ fluid
SurePath™: 2 mL of SurePath™ fluid
Minimum Volume
ThinPrep®: 1.5 mL
SurePath™: 1 mL
SurePath™: 1 mL
Instructions
Collect the sample as usual according to the manufacturer's instructions
Transport Temperature
Room temperature
Specimen Stability
Thin Prep
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable
SurePath™
Room temperature: 28 days
Refrigerated: 90 days
Frozen: Unacceptable
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable
SurePath™
Room temperature: 28 days
Refrigerated: 90 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Cervical swabs in Digene® HC cervical sampler • Unprocessed Cytyc® media without cervical brush/broom • Swabs • Digene® vials • SurePath™ pellet • Samples treated with Acetic Acid • Vaginal sources
Methodology
Real-Time Polymerase Chain Reaction
Setup Schedule
Sets up 3 days a week.
Clinical Significance
Persistent infection with high-risk HPV types increases a woman's risk for progression to dysplasia or cervical cancer. The rate of progression or degree of risk depends on the HPV type. Of all various high-risk types, HPV Types 16 and 18 cause more than 60-65% of cervical cancers. This test will identify the presence or absence of HPV Type 16 DNA and /or Type 18 DNA. Knowledge of the HPV genotype will help physicians diagnose the type of HPV infection and its risk of developing into dysplasia or cervical cancer.
