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Cholinesterase, Serum, Plasma, RBC (California Clients)
Test Code90369
CPT Codes
82480 (x2), 82482<br>**This code is for California patients. For non-California testing, use 39481. **
Preferred Specimen
5 mL uncentrifuged whole blood collected in an EDTA (lavender-top) tube and
1 mL plasma collected in an EDTA (lavender-top) tube and
1 mL serum
1 mL plasma collected in an EDTA (lavender-top) tube and
1 mL serum
Minimum Volume
4 mL whole blood • 0.5 mL plasma • 0.5 mL serum
Other Acceptable Specimens
Plasma collected in: PPT potassium EDTA (white-top) tube
Instructions
Transfer plasma and serum to transport tubes and send refrigerated with whole blood.
Note: PPT potassium EDTA (white-top) tubes should be centrifuged within 24 hours
Note: PPT potassium EDTA (white-top) tubes should be centrifuged within 24 hours
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: Unacceptable
Refrigerated: 7 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Kinetic Spectrophotometric (KS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 5 days a week.
Clinical Significance
True cholinesterase (RBC and plasma) activity is decreased in individuals with exposure to organophosphorous insecticides. True cholinesterase, found in erythrocytes and nerve tissue, is responsible for inactivating acetylcholinesterase at nerve endings. With decreased enzyme activity, patients may display a range of nervous system dysfunction. Analysis of RBC and serum or plasma activity is useful in monitoring exposure and recovery.
