A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
(CTC) Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Analysis
Test Code715538
CPT Codes
*ERRO (x0) 99199
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
5 mL Whole blood.
Collection Instructions:
__** This test is not available for New York patient
__testing. **
__
__Physician Attestation of Informed Consent - This germline
__genetic test requires physician attestation that patient
__consent has been received. Whole blood: Normal phlebotomy
__procedure. Specimen stability is crucial. Store and ship
__ambient immediately. Do not freeze.
Collection Instructions:
__** This test is not available for New York patient
__testing. **
__
__Physician Attestation of Informed Consent - This germline
__genetic test requires physician attestation that patient
__consent has been received. Whole blood: Normal phlebotomy
__procedure. Specimen stability is crucial. Store and ship
__ambient immediately. Do not freeze.
Minimum Volume
3 mL Whole blood
Transport Container
Whole blood
__EDTA (lavender-top) (preferred)
__ACD solution B (yellow-top) (preferred)
__ACD solution A (yellow-top)
__Lithium heparin (green-top)
__Sodium heparin (green-top)
__EDTA (lavender-top) (preferred)
__ACD solution B (yellow-top) (preferred)
__ACD solution A (yellow-top)
__Lithium heparin (green-top)
__Sodium heparin (green-top)
Transport Temperature
Whole blood: Room temperature preferred; Refrigerated
_unacceptable; Frozen unacceptable
_unacceptable; Frozen unacceptable
Specimen Stability
Whole blood
__Room temperature: 8 Days
__Refrigerated: 8 Days
__Frozen: Do Not Freeze
__-70 Degrees: Do Not Freeze
__Room temperature: 8 Days
__Refrigerated: 8 Days
__Frozen: Do Not Freeze
__-70 Degrees: Do Not Freeze
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples received frozen.
Methodology
Polymerase Chain Reaction, Single Nucleotide Primer Extension
Setup Schedule
A.M. Sets up 2 days a week.
Report Available
Reports in 6 to 10 days.
Clinical Significance
Partial or complete deficiency of DPD activity has been
associated with an increased risk for severe adverse
reactions when treated with pyrimidine-based
chemotherapeutic agents, such as 5-fluorouracil (5-FU).
The test can also be used to confirm the clinical
diagnosis of dihydropyrimidine dehydrogenase (DPD)
deficiency in affected patients and for the detection of
the IVS14+1G>A mutation in asymptomatic carriers.
associated with an increased risk for severe adverse
reactions when treated with pyrimidine-based
chemotherapeutic agents, such as 5-fluorouracil (5-FU).
The test can also be used to confirm the clinical
diagnosis of dihydropyrimidine dehydrogenase (DPD)
deficiency in affected patients and for the detection of
the IVS14+1G>A mutation in asymptomatic carriers.