17-Hydroxyprogesterone Response to ACTH (Baseline, 30, 60) (Client 5220)

Test Code

4952CS

CPT Codes
83498 (x3)<br>** This test is available for clients 1296, 2244, 5220, 6666, 8460, 8807, 53380, 55235 and 6464 ONLY**<br><br data-cke-filler="true">

Preferred Specimen

1 mL serum (x3) collected in red-top tubes (no gel)

Minimum Volume

0.5 mL (x3)

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top), EDTA (royal blue-top), sodium heparin (green-top), or lithium heparin (green-top) tubes

Instructions

Draw baseline specimen. Draw another specimen 60 minutes after stimulation.

Serum Separator Tubes (SST®) are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.

Note: Cortrosyn (cosyntropin) not supplied by the laboratory. This test cannot be collected at a Patient Service Center.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 2 years

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator Tubes (SST®)

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

A.M. Sets up 6 days a week

Clinical Significance

17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.