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Gentamicin, Peak and Trough (Client 53380)
Test Code32669
CPT Codes
Restricted Client Code - All other clients should use test code 444
Preferred Specimen
1 mL serum (x2) collected in red-top tubes (no gel)
Patient Preparation
Collect peak at the end of 60-minute IV infusion, 30 minutes after the end of 30-minute IV infusion or 60 minutes after the IM dose. Collect as trough just before next dose.
Minimum Volume
0.2 mL (x2)
Other Acceptable Specimens
1 mL plasma collected in EDTA (lavender-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: Unacceptable
Refrigerated: 7 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube
Methodology
Immunoassay
Setup Schedule
Set up: Tues-Sat; Report available: 3 days
Clinical Significance
Gentamicin is an aminoglycoside antibiotic used in the
treatment of gram-positive and gram-negative bacterial
infections, especially Pseudomonas, Proteus, Klebsiella and
Staphylococcus. Gentamicin is potentially nephrotoxic and
ototoxic. Serial monitoring of peak and trough serum levels
may provide the clinician with information to maintain safe
and therapeutic levels.
treatment of gram-positive and gram-negative bacterial
infections, especially Pseudomonas, Proteus, Klebsiella and
Staphylococcus. Gentamicin is potentially nephrotoxic and
ototoxic. Serial monitoring of peak and trough serum levels
may provide the clinician with information to maintain safe
and therapeutic levels.