| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Lipid Panel with Ratios
Test Code19543
CPT Codes
80061<br><strong>This test is not available for New York patient testing</strong>
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
1 mL serum collected in a serum separator tube (SST), received spun
Patient Preparation
If a cholesterol measurement is to be performed along with triglycerides, but not part of a lipid panel, then the patient should be fasting 9-12 hours prior to collection. If the cholesterol is ordered as part of a lipid panel, then a fasting sample is not required.
The assay manufacturer Beckman Coulter advises:
N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been...determined to interfere with assays for...cholesterol, uric acid where NAC interference may lead to falsely low results. According to Beckman Coulter, the NAC interference should be insignificant by 12 hours after completion of the initial loading dose of an IV infusion treatment regimen consisting of an initial loading dose of 150 mg/kg administered over 1 hour, a second dose of 50 mg/kg administered over 4 hours and a third dose of 100 mg/kg administered over 16 hours.
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in a sodium or lithium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Serum
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 28 days
Plasma
Room temperature: 48 hours
Refrigerated: 48 hours
Frozen: 28 days
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 28 days
Plasma
Room temperature: 48 hours
Refrigerated: 48 hours
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Anticoagulants other than heparin • Moderate to gross icterus
Methodology
Spectrophotometry
Setup Schedule
Sets up 7 days a week.
Clinical Significance
This panel measures serum cholesterol and triglyceride (TG) levels. It includes evaluation of the LDL/HDL ratio (calculated), cholesterol/HDL-C ratio (calculated), HDL-C, LDL-C (calculated), non-HDL-C (calculated), total cholesterol, and TG. Comprehensive lipid assessment aids in evaluating cardiovascular disease (CVD) risk and the likelihood of an ischemic event. It is also useful for the prevention and management of atherosclerotic disease and diagnosis of metabolic syndrome [1].
CVD is the leading cause of death in the United States. Individuals with high LDL-C and TG levels are at elevated risk for developing CVD and having an ischemic event [2,3]. The American Heart Association recommends that Americans aged 20 and above have their lipid levels tested every 4 to 6 years. Children should have their cholesterol tested for the first time between ages 9 and 11 and again between ages 17 and 21. Testing should start earlier if there is a family history of high cholesterol [4].
This panel reports a calculated LDL/HDL ratio in addition to all the components included in Lipid Panel, Standard (test code 7600). High LDL/HDL ratio may be a stronger predictor of coronary heart disease than LDL and HDL alone in patients with hypertriglyceridemia [5].
Treatment with N-acetyl cysteine for acetaminophen overdose may generate a falsely low result for cholesterol [6]. Venipuncture immediately after or during administration of the painkiller metamizole (dipyrone) may also lead to falsely low results for cholesterol [7].
Note: Any or all individual tests from a panel can be ordered separately.
The results of this test should be interpreted in the context of pertinent clinical and family history as well as physical examination findings.
References
1. Stone NJ, et al. Circulation. 2014;129(25 Suppl2):S1-S45.
2. CDC. Heart disease facts. Accessed January 3, 2022. https://www.cdc.gov/heartdisease/facts.htm
3. Arbel Y, et al. Card Diabetol. 2016;15:11.
4. Grundy SM, et al. Circulation. 2019;139(25):e1082-e1143.
5. Manninen V, et al. Circulation. 1992;85(1):37-45.
6. Cholesterol. Instructions for use. Beckman Coulter
Inc; 2015.
7. Gascon N, et al. Clin Chem. 1993;39(6):1033-1036.
CVD is the leading cause of death in the United States. Individuals with high LDL-C and TG levels are at elevated risk for developing CVD and having an ischemic event [2,3]. The American Heart Association recommends that Americans aged 20 and above have their lipid levels tested every 4 to 6 years. Children should have their cholesterol tested for the first time between ages 9 and 11 and again between ages 17 and 21. Testing should start earlier if there is a family history of high cholesterol [4].
This panel reports a calculated LDL/HDL ratio in addition to all the components included in Lipid Panel, Standard (test code 7600). High LDL/HDL ratio may be a stronger predictor of coronary heart disease than LDL and HDL alone in patients with hypertriglyceridemia [5].
Treatment with N-acetyl cysteine for acetaminophen overdose may generate a falsely low result for cholesterol [6]. Venipuncture immediately after or during administration of the painkiller metamizole (dipyrone) may also lead to falsely low results for cholesterol [7].
Note: Any or all individual tests from a panel can be ordered separately.
The results of this test should be interpreted in the context of pertinent clinical and family history as well as physical examination findings.
References
1. Stone NJ, et al. Circulation. 2014;129(25 Suppl2):S1-S45.
2. CDC. Heart disease facts. Accessed January 3, 2022. https://www.cdc.gov/heartdisease/facts.htm
3. Arbel Y, et al. Card Diabetol. 2016;15:11.
4. Grundy SM, et al. Circulation. 2019;139(25):e1082-e1143.
5. Manninen V, et al. Circulation. 1992;85(1):37-45.
6. Cholesterol. Instructions for use. Beckman Coulter
Inc; 2015.
7. Gascon N, et al. Clin Chem. 1993;39(6):1033-1036.
