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IGF-I, LC/MS (Client 55838)
Test Code16293CS
CPT Codes
84305
Preferred Specimen
0.5 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.3 mL
Instructions
Collect blood in a red-top or SST vacutainer. For red-top vacutainers, allow blood to clot (10-15 minutes) at room temperature. Separate serum from cells and refrigerate.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated:7 days
Frozen: 60 days
Refrigerated:7 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Liquid Chromatography Mass Spectrometry
Setup Schedule
Set up: Sun-Fri; Report available: 2-5 days
Clinical Significance
Insulin-like growth factor 1 (IGF-1, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
