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Cryptococcal Antigen, Latex Screen with Reflex to Titer
Test Code11196
CPT Codes
86403
Includes
If Cryptococcal Antigen Screen is Detected, then Cryptococcal Antigen, Latex Titer will be performed at an additional charge (CPT code(s): 86406).
Preferred Specimen
1 mL CSF in a sterile plastic screw cap container
Minimum Volume
0.5 mL CSF or serum
Other Acceptable Specimens
2 mL serum
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to clean, plastic, screw-capped vial(s). Refrigerate samples and transport on refrigerant coolant or freeze samples and transport on dry ice to the laboratory.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 60 days
Refrigerated: 7 days
Frozen: 60 days
Methodology
Latex Agglutination (LA)
Setup Schedule
Set up: Tues-Sat; Report available: 1-3 days
Limitations
Patients with capnocytophaga canimorsus and tichosporon beigelli infections may test falsely-positive.
Clinical Significance
The encapsulated soil yeast Cryptococcus neoformans causes Cryptococcosis. Pulmonary infection is acquired by inhalation of the organism and is usually subclinical in the immunocompetent host. Dissemination may occur in an immunocompromised patient, often to the meninges.
