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Drug Monitoring, Amphetamines, with D/L, Quantitative, Urine
Test Code39386
CPT Codes
80324 (HCPCS: G0480)
Includes
If you require medMATCH for this order code, you must also order code 39158 - Prescribed Drugs, medMATCH®. If 39158 is ordered, all Drug Monitoring order codes will be treated as medMATCH.
If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d.
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Amphetamine and Methamphetamine
If the Methamphetamine is reported Positive (≥250 ng/mL), Pain Management, Methamphetamine, D/L Isomers, Urine will be performed at an additional charge (CPT code(s): 80374 HCPCS: G0480)
If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d.
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Amphetamine and Methamphetamine
If the Methamphetamine is reported Positive (≥250 ng/mL), Pain Management, Methamphetamine, D/L Isomers, Urine will be performed at an additional charge (CPT code(s): 80374 HCPCS: G0480)
Preferred Specimen
9 mL urine in a clinical drug test transport vial
Minimum Volume
5 mL
Other Acceptable Specimens
Urine collected in urine collection container
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved samples
Methodology
Mass Spectrometry (MS)
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Clinical Significance
Methamphetamine has two isomers, d-methamphetamine (dextromethamphetamine) and l-methamphetamine (levomethamphetamine). d-methamphetamine is most often illicitly manufactured and is considered a drug of abuse (Crystal meth, etc.). It is approved as a treatment for ADHD and obesity, although its use is very limited. l-methamphetamine is used in certain nonprescription inhalers as a decongestant. This test is a definitive assay using a gas chromatography mass spectroscopy (GC-MS) method of analysis. In routine confirmation testing of amphetamines, the specific methamphetamine isomers are not differentiated, and reported as "Methamphetamine". In situations where this is an unexpected result, it may be useful to determine the relative percentages of each isomer present. The presence of the l-isomer at greater than 80% is consistent with the use of non-prescription inhalers. The presence of the d-isomer greater than 20% is consistent with the use of prescribed medication or illegally manufactured methamphetamine. Quantitative values cannot be used to assess the drug dose, because the drug is extensively metabolized and excreted in the urine.
