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Pyruvate Kinase Enzyme Activity, Blood
Test Code39855
CPT Codes
84220
Preferred Specimen
6 mL whole blood collected in an ACD solution B (yellow-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Whole blood collected in: EDTA (lavender-top) tube
Instructions
Send specimen in original tube. Do not transfer blood to other containers.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 20 days
Frozen: Unacceptable
Refrigerated: 20 days
Frozen: Unacceptable
Methodology
Kinetic Spectrophotometry
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
Setup Schedule
Set up: Mon-Sat; Report available: 1 day
Clinical Significance
Evaluation of nonspherocytic hemolytic anemia.
Evaluation of neonatal anemia or jaundice.
Evaluation of unexplained noninfectious hepatic failure.
Evaluation of iron overload.
Evaluation of unusually severe hemoglobin S trait.
Evaluation of unusually severe glucose 6-phosphate dehydrogenase deficiency.
Investigating families with pyruvate kinase deficiency to determine inheritance patten and for genetic counseling.
Evaluation of neonatal anemia or jaundice.
Evaluation of unexplained noninfectious hepatic failure.
Evaluation of iron overload.
Evaluation of unusually severe hemoglobin S trait.
Evaluation of unusually severe glucose 6-phosphate dehydrogenase deficiency.
Investigating families with pyruvate kinase deficiency to determine inheritance patten and for genetic counseling.
